Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period
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Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period
The core circadian oscillator in mammals is composed of transcription/translation feedback loop, in which cryptochrome (CRY) proteins play critical roles as repressors of their own gene expression. Although post-translational modifications, such as phosphorylation of CRY1, are crucial for circadian rhythm, little is known about how phosphorylated CRY1 contributes to the molecular clockwork. To ...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2016
ISSN: 1664-2295
DOI: 10.3389/fneur.2016.00159